| 5 | Sense North | Hospitals/Childcare/Caring Premises | Hyndburn | BB5 1ST |
| 5 | Shabs News | Retailers - other | Hyndburn | BB5 0AQ |
| 5 | Shaha Joli Indian Take Away Ltd | Takeaway/sandwich shop | Hyndburn | BB5 5DT |
| 3 | Sherwood | Hospitals/Childcare/Caring Premises | Hyndburn | BB1 4DW |
| 5 | Silcock's Catering | Mobile caterer | Hyndburn | BB5 |
| 4 | Simply Indian Takeaway | Takeaway/sandwich shop | Hyndburn | BB5 3EG |
| 5 | Sipps | Restaurant/Cafe/Canteen | Hyndburn | BB5 1EE |
| Exempt | Slimming World Franchise | Retailers - other | Hyndburn | BB5 |
| 3 | Smash & Eat | Takeaway/sandwich shop | Hyndburn | BB5 1LE |
| 3 | Smash Guys | Takeaway/sandwich shop | Hyndburn | BB5 1HB |
| 5 | Smith's Event Catering ( P288 EPY ) | Mobile caterer | Hyndburn | BB5 |
| 5 | Smiths Fresh Produce | Retailers - other | Hyndburn | BB5 1JJ |
| 4 | Snuffy Arrods | Restaurant/Cafe/Canteen | Hyndburn | BB6 7UD |
| 5 | Sodexo @ Highfield House | Hotel/bed & breakfast/guest house | Hyndburn | BB5 0PX |
| 5 | Space 2 Make | Restaurant/Cafe/Canteen | Hyndburn | BB5 1LE |
| 5 | Spar Store | Retailers - supermarkets/hypermarkets | Hyndburn | BB5 6DW |
| 5 | Spar Stores | Retailers - supermarkets/hypermarkets | Hyndburn | BB5 4QG |
| 5 | Sparth House Hotel | Hotel/bed & breakfast/guest house | Hyndburn | BB5 5RP |
| 5 | Sparthfield Happy Day Nursery | Hospitals/Childcare/Caring Premises | Hyndburn | BB5 5RP |
| Awaiting | Spice and Fire | Takeaway/sandwich shop | Hyndburn | BB5 1AR |
| 5 | Spitting Pig Lancashire | Mobile caterer | Hyndburn | BB5 5SW |
| Exempt | Sports Direct | Retailers - other | Hyndburn | BB5 1EY |
| 4 | Spring Garden | Takeaway/sandwich shop | Hyndburn | BB5 3JD |
| 4 | Spring Hill Convenience Store- Open All Hours | Retailers - other | Hyndburn | BB5 0EX |
| 5 | Springhill Care Home | Hospitals/Childcare/Caring Premises | Hyndburn | BB5 0LD |
| 5 | Spud Bros Express Blackburn @ Frontier Park | Restaurant/Cafe/Canteen | Hyndburn | BB1 3HR |
| 4 | Spud Cafe | Restaurant/Cafe/Canteen | Hyndburn | BB5 1AR |
| 5 | St Andrew's Out of School Club | School/college/university | Hyndburn | BB5 3LG |
| 5 | St Charles After School club | School/college/university | Hyndburn | BB1 4HT |
| 4 | St Christophers CE High School | School/college/university | Hyndburn | BB5 4AY |
| 5 | St Johns School Annex | School/college/university | Hyndburn | BB6 7ER |
| 5 | St Mary Magdalen's Out of School Club | School/college/university | Hyndburn | BB5 1DW |
| 5 | St Marys RC Primary School | School/college/university | Hyndburn | BB5 3AA |
| 4 | St Nicholas CE Primary School | School/college/university | Hyndburn | BB5 4DN |
| 5 | St. Andrews C E Primary School | School/college/university | Hyndburn | BB5 3LG |
| 5 | St. Bartholomews C E Primary School | School/college/university | Hyndburn | BB6 7QA |
| 5 | St. Johns C of E Primary School | School/college/university | Hyndburn | BB6 7ES |
| 5 | St. Mary's R C Primary School | School/college/university | Hyndburn | BB5 5RJ |
| 5 | St. Oswalds RC Primary School | School/college/university | Hyndburn | BB5 0NN |
| 5 | St. Pauls C E Primary School | School/college/university | Hyndburn | BB5 3DD |
| 4 | St. Wulstans RC School | School/college/university | Hyndburn | BB6 7JQ |
| 4 | Stanhill Preschool | Hospitals/Childcare/Caring Premises | Hyndburn | BB5 4QT |
| 5 | Stanhill Working Mens Club | Pub/bar/nightclub | Hyndburn | BB5 4PP |
| 4 | Star East | Takeaway/sandwich shop | Hyndburn | BB5 3EU |
| 5 | Starbucks | Restaurant/Cafe/Canteen | Hyndburn | BB1 3AL |
| 4 | Stop & Rest | Pub/bar/nightclub | Hyndburn | BB5 3BE |
| 5 | Stotts Craft Bakery | Retailers - other | Hyndburn | BB1 4LA |
| 5 | Suarez tasty bites | Takeaway/sandwich shop | Hyndburn | BB1 4LQ |
| 5 | Subway | Restaurant/Cafe/Canteen | Hyndburn | BB5 1PL |
| 5 | Subway | Takeaway/sandwich shop | Hyndburn | BB1 3AL |