| Awaiting | Rowlands Pharmacy Mayfield (Branch 1744) | Retailers - other | Midlothian | EH22 4AA |
| Pass | Royal British Legion | Pub/bar/nightclub | Midlothian | EH25 9LN |
| Pass | Royal Voluntary Service Cafe | Restaurant/Cafe/Canteen | Midlothian | EH22 3ND |
| Pass | Rutherford's | Takeaway/sandwich shop | Midlothian | EH19 3BB |
| Pass | Sacred Heart Primary School | School/college/university | Midlothian | EH26 9BB |
| Pass | Sacred Heart Primary School Nursery | Hospitals/Childcare/Caring Premises | Midlothian | EH26 9BB |
| Pass | Salters Inn Ltd | Pub/bar/nightclub | Midlothian | EH22 2DQ |
| Pass | Saltire Hospitality Ltd | Manufacturers/packers | Midlothian | EH20 9JL |
| Exempt | Saltire Patisserie Ltd | Manufacturers/packers | Midlothian | EH20 9JL |
| Pass | Saltire Soccer Ltd | Restaurant/Cafe/Canteen | Midlothian | EH22 4AD |
| Pass | Sawasdee Snax | Mobile caterer | Midlothian | EH22 |
| Pass | Scallywags Childrens Nursery Loanhead | Hospitals/Childcare/Caring Premises | Midlothian | EH20 9RP |
| Pass | School's Out Penicuik | School/college/university | Midlothian | EH26 8AG |
| Pass | Scotmid | Retailers - other | Midlothian | EH20 9RE |
| Pass | Scotmid | Retailers - other | Midlothian | EH22 4NE |
| Pass | Scotmid | Retailers - supermarkets/hypermarkets | Midlothian | EH25 9LR |
| Pass | Scotmid | Retailers - supermarkets/hypermarkets | Midlothian | EH22 5JG |
| Pass | Scotmid | Retailers - supermarkets/hypermarkets | Midlothian | EH23 4TX |
| Pass | ScotsCorner Early Learning and Childcare Centre | Hospitals/Childcare/Caring Premises | Midlothian | EH26 0EW |
| Pass | Sea Garden Chinese Takeaway | Restaurant/Cafe/Canteen | Midlothian | EH23 4AW |
| Exempt | Seaveg | Importers/Exporters | Midlothian | EH25 9LN |
| Pass | Secret Garden Distillery Ltd | Manufacturers/packers | Midlothian | EH20 9LZ |
| Exempt | Secret Garden Distillery Ltd | Manufacturers/packers | Midlothian | EH10 7EA |
| Impr. | Seeds of Sweet Ltd | Distributors/Transporters | Midlothian | EH20 9NP |
| Pass | Seilich Limited | Manufacturers/packers | Midlothian | EH37 5UQ |
| Pass | Sensation Kebab House | Restaurant/Cafe/Canteen | Midlothian | EH22 4PF |
| Pass | Shell Garage | Retailers - other | Midlothian | EH23 4LZ |
| Pass | Shottstown Miners Welfare | Pub/bar/nightclub | Midlothian | EH26 8AT |
| Pass | Side Street Burgers | Takeaway/sandwich shop | Midlothian | EH19 3PZ |
| Awaiting | Slumdog Dalkeith Ltd | Restaurant/Cafe/Canteen | Midlothian | EH22 1AY |
| Exempt | Somerset Distribution UK Ltd t/a Shibui Tea | Distributors/Transporters | Midlothian | EH20 9HN |
| Pass | Soup Kitchen | Other catering premises | Midlothian | EH26 0QB |
| Pass | Spar | Retailers - other | Midlothian | EH20 9HB |
| Pass | Spar Dalkeith | Retailers - other | Midlothian | EH22 2BP |
| Pass | Spar Store | Retailers - supermarkets/hypermarkets | Midlothian | EH19 3HB |
| Impr. | Spice House | Takeaway/sandwich shop | Midlothian | EH26 8LH |
| Impr. | Spice Of Penicuik | Takeaway/sandwich shop | Midlothian | EH26 8NP |
| Pass | Spire Shawfair Park Hospital | Hospitals/Childcare/Caring Premises | Midlothian | EH22 1FE |
| Awaiting | Splendidly Scottish | Retailers - other | Midlothian | EH26 8HA |
| Pass | Springfield Bank Care Centre - HC-One | Hospitals/Childcare/Caring Premises | Midlothian | EH19 3PN |
| Pass | Springfield Game & Country Meats | Retailers - other | Midlothian | EH26 |
| Pass | Sprinkled With Sweetness | Manufacturers/packers | Midlothian | EH23 |
| Pass | St Andrews Primary School | School/college/university | Midlothian | EH23 4DA |
| Pass | St Andrews Primary School Nursery | Hospitals/Childcare/Caring Premises | Midlothian | EH23 4DA |
| Pass | St Annes Social Committee | Other catering premises | Midlothian | EH22 4NQ |
| Awaiting | St David's Primary School Nursery | Hospitals/Childcare/Caring Premises | Midlothian | EH22 2PU |
| Exempt | St Davids Bradbury Day Centre | Hospitals/Childcare/Caring Premises | Midlothian | EH22 4LF |
| Pass | St Davids Primary School | School/college/university | Midlothian | EH22 2PU |
| Pass | St John's And Kings Park Church | Restaurant/Cafe/Canteen | Midlothian | EH22 1HJ |
| Impr. | St Joseph's Service | Hospitals/Childcare/Caring Premises | Midlothian | EH24 9DN |