| 5 | SLUG AND LETTUCE | Pub/bar/nightclub | Newcastle-Under-Lyme | ST5 1PS |
| 5 | SMAKOLYK FOOD PLUS | Retailers - other | Newcastle-Under-Lyme | ST5 2AE |
| 5 | SMART INNOVATION HUB CAFE (SIH CAFE) | Restaurant/Cafe/Canteen | Newcastle-Under-Lyme | ST5 5BG |
| 4 | SMASH CASTLE NEWCASTLE | Takeaway/sandwich shop | Newcastle-Under-Lyme | ST5 1PT |
| 5 | SMASH YA FACE IN | Retailers - other | Newcastle-Under-Lyme | ST7 |
| 5 | SNEYD ARMS | Pub/bar/nightclub | Newcastle-Under-Lyme | ST5 2TG |
| 5 | SNEYD ARMS | Pub/bar/nightclub | Newcastle-Under-Lyme | ST5 5AD |
| Awaiting | SNOWWWW GOOD! | Retailers - other | Newcastle-Under-Lyme | ST7 |
| 5 | SOCIAL SERVICES RESPITE CARE UNIT | Hospitals/Childcare/Caring Premises | Newcastle-Under-Lyme | ST5 9BJ |
| 5 | SODEXO GOVERNMENT SERVICES | Retailers - other | Newcastle-Under-Lyme | ST5 1HJ |
| 5 | SOLO PIZZA MARGHERITA | Mobile caterer | Newcastle-Under-Lyme | ST5 |
| 5 | SOUTHLANDS CRECHE | Hospitals/Childcare/Caring Premises | Newcastle-Under-Lyme | ST5 0HU |
| 5 | SOUTHLANDS NURSERIES LTD | Hospitals/Childcare/Caring Premises | Newcastle-Under-Lyme | ST5 8BZ |
| 5 | SPICE BOX CATERING | Retailers - other | Newcastle-Under-Lyme | ST5 |
| 1 | SPICE MERCHANT EXPRESS | Takeaway/sandwich shop | Newcastle-Under-Lyme | ST7 1LX |
| 5 | SPORTSDIRECT.COM | Retailers - other | Newcastle-Under-Lyme | ST5 1AN |
| 5 | SPRINGHEAD BEFORE & AFTER SCHOOL CLUB | Hospitals/Childcare/Caring Premises | Newcastle-Under-Lyme | ST7 1RA |
| 5 | SPRINGHEAD COMMUNITY PRIMARY SCHOOL - EDWARDS & WARD LTD | School/college/university | Newcastle-Under-Lyme | ST7 1RA |
| 5 | ST CHAD'S C of E PRIMARY SCHOOL - EDWARDS & WARD LTD | School/college/university | Newcastle-Under-Lyme | ST5 7AB |
| 5 | ST GILES & ST GEORGES CARE CLUB | Hospitals/Childcare/Caring Premises | Newcastle-Under-Lyme | ST5 2NB |
| 5 | ST GILES AND ST GEORGES ACADEMY - TAYLORSHAW | School/college/university | Newcastle-Under-Lyme | ST5 2NB |
| 5 | ST JOHN FISHER CATHOLIC COLLEGE | School/college/university | Newcastle-Under-Lyme | ST5 2SJ |
| 4 | ST JOHN THE EVANGELIST CATHOLIC ACADEMY | School/college/university | Newcastle-Under-Lyme | ST7 1EH |
| 5 | ST JOHNS C OF E CP SCHOOL - MIQUILL CATERING LTD | School/college/university | Newcastle-Under-Lyme | ST5 5AF |
| 4 | ST JOHNS CARE CLUB | Hospitals/Childcare/Caring Premises | Newcastle-Under-Lyme | ST5 5AF |
| 5 | ST LUKE'S C OF E PRIMARY SCHOOL - EDWARDS & WARD LTD | School/college/university | Newcastle-Under-Lyme | ST5 6QJ |
| 5 | ST MARGARET'S C OF E JUNIOR SCHOOL - EDWARDS & WARD LTD | School/college/university | Newcastle-Under-Lyme | ST5 0HU |
| Exempt | ST MARK'S CHURCH HALL | Other catering premises | Newcastle-Under-Lyme | ST5 0PG |
| 5 | ST MARY'S CATHOLIC PRIMARY SCHOOL | School/college/university | Newcastle-Under-Lyme | ST5 2TA |
| 3 | ST MARY'S LOCAL STORES | Retailers - other | Newcastle-Under-Lyme | ST5 3DA |
| Awaiting | ST MARYS C OF E PRIMARY SCHOOL - MILQUILL | School/college/university | Newcastle-Under-Lyme | TF9 4DN |
| 5 | ST MICHAELS ORTHODOX CHURCH | Retailers - other | Newcastle-Under-Lyme | ST7 8EN |
| 5 | ST QUENTIN | Hospitals/Childcare/Caring Premises | Newcastle-Under-Lyme | ST5 0LZ |
| 5 | ST QUENTIN | Hospitals/Childcare/Caring Premises | Newcastle-Under-Lyme | ST5 0LZ |
| 5 | ST QUENTIN | Hospitals/Childcare/Caring Premises | Newcastle-Under-Lyme | ST5 0LZ |
| 5 | ST SAVIOURS COFE ACADEMY - MIQUILL CATERING | School/college/university | Newcastle-Under-Lyme | ST7 1LW |
| 5 | ST THOMAS BEFORE AND AFTER SCHOOL CLUB | Hospitals/Childcare/Caring Premises | Newcastle-Under-Lyme | ST7 4HT |
| 5 | ST THOMAS C OF E PRIMARY SCHOOL - TAYLORSHAW | School/college/university | Newcastle-Under-Lyme | ST7 4HT |
| 5 | ST THOMAS CHURCH (THE WADE CENTRE) | Other catering premises | Newcastle-Under-Lyme | ST7 1AG |
| 5 | ST WULSTAN'S CATHOLIC PRIMARY SCHOOL | School/college/university | Newcastle-Under-Lyme | ST5 0EF |
| Exempt | ST. GILES CHURCH | Retailers - other | Newcastle-Under-Lyme | ST5 1QS |
| 5 | STAFF COMMON ROOM BAR | Pub/bar/nightclub | Newcastle-Under-Lyme | ST5 5BA |
| 5 | STARBUCKS (SOUTH) | Restaurant/Cafe/Canteen | Newcastle-Under-Lyme | ST5 5HG |
| 5 | STARBUCKS - NORTH | Restaurant/Cafe/Canteen | Newcastle-Under-Lyme | ST5 5DA |
| 5 | STARBUCKS - NORTH DRIVE THRU | Restaurant/Cafe/Canteen | Newcastle-Under-Lyme | ST5 5HG |
| 5 | STARBUCKS - SOUTH DRIVE THRU | Restaurant/Cafe/Canteen | Newcastle-Under-Lyme | ST5 5HG |
| 5 | STARBUCKS COFFEE COMPANY UK LIMITED | Restaurant/Cafe/Canteen | Newcastle-Under-Lyme | ST5 0AP |
| 5 | STARBUCKS COFFEE SHOP | Restaurant/Cafe/Canteen | Newcastle-Under-Lyme | ST5 2GB |
| 5 | STARBUCKS HOLDITCH | Other catering premises | Newcastle-Under-Lyme | ST5 7PJ |
| 5 | STATION STORES | Retailers - other | Newcastle-Under-Lyme | ST5 5BU |