| 5 | Repton's Little Critters Out of School | Hospitals/Childcare/Caring Premises | South Derbyshire | DE65 6GN |
| 5 | Richmond Village Aston on Trent | Hospitals/Childcare/Caring Premises | South Derbyshire | DE72 2EA |
| 5 | Rising Sun | Pub/bar/nightclub | South Derbyshire | DE65 6BP |
| Exempt | Rob White | Retailers - other | South Derbyshire | DE11 7AS |
| 5 | Robin Hood Inn | Pub/bar/nightclub | South Derbyshire | DE12 6LQ |
| 5 | Root and Ribbon | Other catering premises | South Derbyshire | DE11 |
| 5 | Rosliston Church Of England Primary School | School/college/university | South Derbyshire | DE12 8JW |
| 5 | Rosliston Fish Bar | Takeaway/sandwich shop | South Derbyshire | DE12 8JW |
| Exempt | Rosliston Forestry Centre | Retailers - other | South Derbyshire | DE12 8JX |
| 5 | Rosliston Under 5's Pre-School | Hospitals/Childcare/Caring Premises | South Derbyshire | DE12 8JW |
| 5 | Royal British Legion Club | Pub/bar/nightclub | South Derbyshire | DE65 6GD |
| 5 | Royal Oak | Pub/bar/nightclub | South Derbyshire | DE11 0HP |
| 5 | Royle Forest Wedding Limited | Other catering premises | South Derbyshire | DE15 9TU |
| 5 | Ruth's Absolutely Scrumptious Cake Co. | Other catering premises | South Derbyshire | DE65 |
| 5 | Ryan James Butchery | Retailers - other | South Derbyshire | DE11 0TX |
| 5 | S & L Caterers | Mobile caterer | South Derbyshire | DE11 |
| 5 | S Collier Butchers | Retailers - other | South Derbyshire | DE11 8JA |
| 5 | SKC Supper Clubs LTD | Other catering premises | South Derbyshire | DE65 |
| 5 | Saffron Event and Venue Caterers Ltd., The Glade | Other catering premises | South Derbyshire | DE12 8JX |
| 5 | Sainsbury Swadlincote Glamorgan Way Local | Retailers - supermarkets/hypermarkets | South Derbyshire | DE11 9JT |
| 5 | Sainsbury's | Retailers - supermarkets/hypermarkets | South Derbyshire | DE11 0AD |
| 5 | Sainsbury's Melbourne Derby Road Local | Retailers - supermarkets/hypermarkets | South Derbyshire | DE73 8FE |
| 5 | Sainsbury's Supermarkets Ltd | Retailers - supermarkets/hypermarkets | South Derbyshire | DE11 0HU |
| 5 | Sainsbury's Swadlincote Burton Road Local | Retailers - supermarkets/hypermarkets | South Derbyshire | DE11 7ND |
| 5 | Sale & Davys CE Primary School Breakfast Club | School/college/university | South Derbyshire | DE73 1HA |
| 5 | Sale and Davy's CE (Controlled) Primary School | School/college/university | South Derbyshire | DE73 7HA |
| 5 | Sale and Davys Playgroup | Hospitals/Childcare/Caring Premises | South Derbyshire | DE73 7HA |
| Exempt | Salts Upstairs | Retailers - other | South Derbyshire | DE11 8HY |
| 5 | Salvation Army - Community Lunch Provision | Other catering premises | South Derbyshire | DE11 9BN |
| 4 | Salvation Army Drop In Cafe | Restaurant/Cafe/Canteen | South Derbyshire | DE11 9PR |
| 5 | Sam's BBQ | Retailers - other | South Derbyshire | DE11 0EW |
| 4 | Sam's Snacks | Mobile caterer | South Derbyshire | DE73 7HZ |
| 5 | Santis Cafe | Restaurant/Cafe/Canteen | South Derbyshire | DE24 3JG |
| 5 | Sarah's Cheesecake Delights | Manufacturers/packers | South Derbyshire | DE11 |
| 5 | Say Cheese | Mobile caterer | South Derbyshire | DE3 0HH |
| 5 | Scaddows Farm Shop & Cafe | Restaurant/Cafe/Canteen | South Derbyshire | DE73 7JP |
| 5 | Scallywags Private Day Nursery/Hero Town | Hospitals/Childcare/Caring Premises | South Derbyshire | DE73 8JB |
| 5 | Scropton Horse Centre | Retailers - other | South Derbyshire | DE65 5PL |
| 5 | Seaking Fish Bar T/A Kebab Box | Takeaway/sandwich shop | South Derbyshire | DE11 0PG |
| 5 | Seale Pastures House | Hospitals/Childcare/Caring Premises | South Derbyshire | DE12 8AP |
| Exempt | Sealwood Cottage Farm | Manufacturers/packers | South Derbyshire | DE12 6PA |
| 4 | Select & Save | Retailers - other | South Derbyshire | DE11 0QF |
| Awaiting | Shadow 1 Airsoft | Retailers - other | South Derbyshire | DE73 7FZ |
| Awaiting | Shakespeare Inn | Pub/bar/nightclub | South Derbyshire | DE72 2GP |
| 5 | Shardlow Hall Private Day Nursery | Hospitals/Childcare/Caring Premises | South Derbyshire | DE72 2GP |
| 5 | Shardlow Honey | Manufacturers/packers | South Derbyshire | DE72 |
| 5 | Shardlow Manor Care Home | Hospitals/Childcare/Caring Premises | South Derbyshire | DE72 2GP |
| 5 | Shardlow Primary School | School/college/university | South Derbyshire | DE72 2GR |
| 5 | Shardlow Primary School Before & After Club | School/college/university | South Derbyshire | DE72 2GR |
| 5 | Shardlow Village Hall Senior Residents Luncheon Club | Other catering premises | South Derbyshire | DE72 2GH |