| 5 | Coundon and Leeholme Early Years Centre C.I.C | Hospitals/Childcare/Caring Premises | Durham | DL14 8NP |
| 5 | Crusty's | Takeaway/sandwich shop | Darlington | DL1 4XJ |
| 5 | Cupcakes For All | Other catering premises | Durham | DL14 |
| Exempt | Currys | Retailers - other | Darlington | DL1 4PU |
| 5 | Darlington Manor Residential Home | Hospitals/Childcare/Caring Premises | Darlington | DL1 4AZ |
| 5 | Daybreak Nursery | Hospitals/Childcare/Caring Premises | Durham | DL14 0HW |
| Exempt | Deaconstar | Hospitals/Childcare/Caring Premises | Durham | DL14 |
| Exempt | Deaconstar | Hospitals/Childcare/Caring Premises | Durham | DL14 |
| Exempt | Deaconstar | Hospitals/Childcare/Caring Premises | Durham | DL14 |
| 5 | Deaconstar | Hospitals/Childcare/Caring Premises | Durham | DL14 7DS |
| 5 | Deaconstar | Hospitals/Childcare/Caring Premises | Durham | DL14 7DS |
| 5 | Demaggio Pizzeria | Takeaway/sandwich shop | Durham | DL14 7EJ |
| 5 | Dene Valley Community Cafe | Takeaway/sandwich shop | Durham | DL14 8TD |
| 4 | Devine Desserts | Restaurant/Cafe/Canteen | Durham | DL14 6JA |
| 5 | Devonshire House Care Home | Hospitals/Childcare/Caring Premises | Durham | DL14 9HW |
| 5 | Domino's Pizza | Takeaway/sandwich shop | Durham | DL14 9TT |
| Awaiting | Doughlicious | Takeaway/sandwich shop | Darlington | DL1 4XJ |
| 5 | Dragon Place | Takeaway/sandwich shop | Darlington | DL1 4SA |
| 5 | Durham Alliance for Community Care | Other catering premises | Durham | DL14 6UR |
| 5 | Durham Careline Ltd | Hospitals/Childcare/Caring Premises | Durham | DL14 9RE |
| 5 | Durham Careline Ltd | Hospitals/Childcare/Caring Premises | Durham | DL14 9RE |
| 5 | Durham Ox | Pub/bar/nightclub | Durham | DL14 8LG |
| 5 | Eastbourne Care Home | Hospitals/Childcare/Caring Premises | Darlington | DL1 4JF |
| 5 | Easyprep | Takeaway/sandwich shop | Darlington | DL1 4YA |
| 5 | Eden Cottage Residential Home | Hospitals/Childcare/Caring Premises | Darlington | DL1 4JF |
| 5 | Eggleston Catering Services At Magnet | Restaurant/Cafe/Canteen | Darlington | DL1 4XT |
| 5 | Eiledon Books | Retailers - other | Durham | DL14 7PG |
| 5 | El Castillo | Restaurant/Cafe/Canteen | Durham | DL14 7NJ |
| 5 | Eldon Community Partnership | Other catering premises | Durham | DL14 8XB |
| 3 | Eldon Lane Convenience Store | Retailers - other | Durham | DL14 8TL |
| 4 | Eldon Lane WMC & Institute Ltd | Pub/bar/nightclub | Durham | DL14 8TL |
| Exempt | Elevated Performance Healthcare | Retailers - other | Darlington | DL1 4QZ |
| 5 | Elior UK | Restaurant/Cafe/Canteen | Darlington | DL1 4BS |
| Exempt | Escomb Community Association | Other catering premises | Durham | DL14 7ST |
| 5 | Escomb Primary School | School/college/university | Durham | DL14 7SR |
| 5 | Etherley Cricket Club | Pub/bar/nightclub | Durham | DL14 0HH |
| 5 | Etherley Lane Nursery School 1024 | School/college/university | Durham | DL14 7RF |
| 4 | Etherley Lane Primary School | School/college/university | Durham | DL14 7RB |
| 5 | Eurest Foodservice | Restaurant/Cafe/Canteen | Darlington | DL1 4BF |
| 5 | Evenwood C of E Primary School | School/college/university | Durham | DL14 9QZ |
| 5 | Evenwood C of E Primary School Breakfast Club | School/college/university | Durham | DL14 9QZ |
| 4 | Evenwood Cafe | Restaurant/Cafe/Canteen | Durham | DL14 9QF |
| 5 | Evenwood Community Action | Retailers - other | Durham | DL14 9QU |
| 4 | Evenwood Community Sports & Social Club Ltd | Pub/bar/nightclub | Durham | DL14 9QB |
| 5 | Evergreen School 7034 | School/college/university | Durham | DL14 6LS |
| 5 | Explorers Day Care Nursery | Hospitals/Childcare/Caring Premises | Durham | DL14 0LZ |
| 4 | Expresso's | Restaurant/Cafe/Canteen | Durham | DL14 7TL |
| 5 | Farmfoods Ltd | Retailers - supermarkets/hypermarkets | Darlington | DL1 4BN |
| 5 | Fifteas Vintage Tearoom | Restaurant/Cafe/Canteen | Durham | DL14 7NJ |
| 5 | First Class Catering | Mobile caterer | Darlington | DL1 4ET |